Phenotype Matching for Sickle Cell Patients: A Review and Recommendations for Transfusion Practice from the CBS

The Canadian Blood Service (CBS) is pleased to offer the following guidance for transfusion of patients with Sickle Cell Disease.

The Key points are:
• Alloimmunisation is common in sickle cell disease patients, and may complicate transfusion therapy.
• Patient phenotyping and prophylactic matching to reduce alloimmunisation is recommended.
• Transfusion requirements and the presence or absence of red cell antibodies influence recommendations on the extent of phenotyping and the utility of genotyping for sickle cell disease patients.

The full guidance can be found here