The Canadian Blood Service (CBS) is pleased to offer the following guidance for transfusion of patients with Sickle Cell Disease.
The Key points are:
• Alloimmunisation is common in sickle cell disease patients, and may complicate transfusion therapy.
• Patient phenotyping and prophylactic matching to reduce alloimmunisation is recommended.
• Transfusion requirements and the presence or absence of red cell antibodies influence recommendations on the extent of phenotyping and the utility of genotyping for sickle cell disease patients.